Karpathy’s advice for the AI classroom

Good morning, AI enthusiasts. Teachers have been fighting a losing battle against AI-generated work — and one among the sphere’s leading voices says it is time to provide up.

Former OpenAI researcher Andrej Karpathy called AI detection tools “doomed to fail,” calling for the education system to rethink how grading and testing are handled in a world where students all have the technology at their fingertips.

In today’s AI rundown:

• Karpathy urges schools to ditch AI homework detection

• Harvard AI pinpoints disease-causing DNA mutations

• Turn any UI right into a landing page with Gemini 3 Pro

• MIT index exposes hidden AI iceberg hitting workforce

• 4 latest AI tools, community workflows, and more

LATEST DEVELOPMENTS

AI & EDUCATION

📚 Karpathy urges schools to ditch AI homework detection

The Rundown: Former OpenAI researcher Andrej Karpathy just urged educators to desert efforts to catch AI-generated homework, arguing detection tools are broken, and that grading must shift back into the classroom within the AI age.

The main points:

• Karpathy said educators will “never have the option to detect” using AI in homework, and that detectors “don’t work” and are “doomed to fail”.

• He cited Google’s Nano Banana Pro, showcasing how it might complete exam problems accurately while mimicking students’ handwriting.

• Karpathy proposed moving graded work to in-school settings over take-home assignments, while embracing AI as a learning companion outside of college.

• He said education’s goal within the AI age needs to be for college kids to be “proficient in using AI” but in addition capable of “exist without it”.

Why it matters: AI has accelerated much faster than schools can prepare for, turning your complete education system on its head with out a clear roadmap for learn how to navigate the changes. With mixed opinions of the tech and implementations various massively, it’s going to take a significant effort to rewire schools for a generation growing up with AI.

TOGETHER WITH GLEAN

💡 Grow to be an Agent of Change at Glean: LIVE

The Rundown: Join Glean’s flagship virtual launch event to fulfill the AI agents changing the long run of labor – and the people behind them. Hear from world-class AI researchers, business leaders, and engineers to see how agentic AI is driving a brand new wave of productivity and collaboration.

Register for Glean: LIVE December ‘25 to:

• Hear research-backed insights on what’s improving how people lead and work with AI

• Meet a brand new sort of AI agent and see product demos of the tech powering the subsequent era

• Explore AI opportunities that empower leaders and builders to alter work for the higher

• Learn best practices for change management as people, agents, and processes evolve

Register now.

HARVARD UNIVERSITY

🧬 Harvard AI pinpoints disease-causing DNA mutations

The Rundown: Harvard Medical School introduced popEVE, a brand new AI genetic evaluation tool that may rank harmful DNA variants across a patient’s entire genome — outperforming DeepMind’s AlphaMissense and significantly cutting false positives.

The main points:

• PopEVE analyzes mutation patterns across a whole lot of 1000’s of species after which calibrates the outcomes against databases of healthy human genomes.

• Researchers applied the model to 31,000 children with severe developmental disorders, solving roughly one-third of cases that had gone undiagnosed.

• The evaluation flagged over 120 genes with no prior connection to the conditions, two dozen of which outside teams have since verified.

• DeepMind’s AlphaMissense flags 44% of individuals as carrying dangerous variants, popEVE drops that figure to 11% after reducing false positives.

Why it matters: There remains to be a lot to be learned about our genome and the causes of rare genetic conditions, and models like PopEVE are coming to crack the code — expanding scientific understanding by surfacing genes nobody knew to search for, and getting real diagnoses to families who’ve spent years without answers.

AI TRAINING

🚀 Turn any UI right into a landing page with Gemini 3 Pro

The Rundown: On this tutorial, you’ll learn learn how to use Gemini 3 Pro to review any UI design from video and switch it into a totally working landing page, complete with animations, interactions, and polished layouts that do not look AI-generated.

Step-by-step:

1. Find UI inspiration on Dribbble, Behance, or any live SaaS site, then download a screen recording of the scrolling page (not only a static screenshot)

2. Upload the video to Gemini 3 Pro (pondering mode on) and prompt: “Study this video and write an in depth prompt describing the UI in depth—layout, colours, typography, animations—then turn it into instructions for a developer”

3. Ask Gemini to convert the evaluation into markdown format for a clean handover document, then copy the total prompt right into a latest Gemini chat

4. Adapt the prompt to your product (swap company name, concept) and add: “Create a high-fidelity interactive landing page based on this design spec and show me a live preview”—then iterate on colours, sections, or animations before exporting to Cursor, Bolt, or Replit for deployment

Pro Tip: Gemini 3.0 is great at analyzing videos for animations and UI specs and turning them into functional landing pages and web sites.

PRESENTED BY YOU.COM

📊 Stop guessing and prove AI ROI

The Rundown: AI spend is rising, but most leaders cannot measure return on investment. This comprehensive guide from You.com provides a step-by-step framework to measure, model, and maximize AI impact.

What’s inside:

• A practical framework for measuring and proving AI’s business value

• 4 ways to calculate ROI, plus when and learn how to use each metric

• A You.com tested LLM prompt to create your individual interactive ROI calculator

Download the AI ROI Guide.

AI RESEARCH

🧊 MIT index exposes hidden AI iceberg hitting workforce

The Rundown: MIT just published a study on AI’s impact on the workforce using its ‘Iceberg Index’, a labor simulation that shows AI can handle tasks value 11.7% of U.S. wages — a number that expands beyond the layoffs visible within the headlines.

The main points:

• The Iceberg Index models 151M American employees across 32,000 skills, showing where AI capabilities overlap with human job functions.

• Tech layoffs represent just 2.2% of total wage exposure (around $211B), while AI’s hidden automation potential in admin and finance is as high as $1.2T.

• Manufacturing states registering little tech-sector impact face the widest gaps, with roles like HR, logistics, and finance showing nearly 10x the exposure risk.

• States including Tennessee, North Carolina, and Utah are already testing workforce policy scenarios on the platform before allocating real budgets.

Why it matters: Most AI workforce coverage focuses on tech industry layoffs, but this index suggests the larger exposure may sit in office and skilled roles spread across every state, not only Silicon Valley — meaning the job displacement problem that many are already warning about might be lots larger than was already estimated.

QUICK HITS

🛠️ Trending AI Tools

• 🤖 Claude Opus 4.5 – Anthropic’s latest benchmark-topping frontier model

• 🍌 Nano Banana Pro – Google’s latest image AI with improved text rendering

• 🏆 Gemini 3 – Google’s latest top-ranked AI model

• 🎆 FLUX.2 – Black Forest Labs’ latest visual intelligence model

📰 All the things else in AI today

OpenAI introduced Voice Mode directly inside ChatGPT’s chat threads, allowing users to leverage the feature in conversations without a completely separate mode.

Character AI rolled out Stories, an interactive AI choose-your-own-adventure experience, designed to craft secure formats for teens.

Anthropic CEO Dario Amodei is being called to testify at a House of Representatives hearing concerning the company’s discovery of an AI cyberattack that used Claude Code.

OpenAI projects ChatGPT will reach 220M paid subscribers by 2030, which might place it among the many world’s largest subscription totals alongside Netflix and Spotify.

Perplexity launched a brand new virtual try-on feature alongside an updated shopping experience, allowing users to view clothing on a virtual avatar of themselves.

HP announced that the corporate is restructuring and cutting 4,000-6,000 jobs on account of the industrywide AI shift, expecting to generate $1B in savings by 2028.

COMMUNITY

🤝 Community AI workflows

Every newsletter, we showcase how a reader is using AI to work smarter, save time, or make life easier.

Today’s workflow comes from reader Kurtis T. in Northland, Recent Zealand:

“I’m a creative while I’m at home and never an engineer. I are inclined to busy myself with multiple side projects across the house. I exploit ChatGPT 5.1 to administer different projects, whether it’s my food gardens, brand design, or training programs.

Utilizing the projects setting, I’m capable of file separate projects and add resource files from various places to that specific project, giving that conversation more specific reference points. All the things is organized and in its right spot, and I can simply return into that project and kick it back off as if I had not left.”

How do you utilize AI? Tell us here.

🎓 Highlights: News, Guides & Events

• Read our last AI newsletter: Ilya Sutskever breaks silence on AI’s future

• Read our last Tech newsletter: This device wiretaps your ‘second brain’

• Read our last Robotics newsletter: Figure sued over ‘skull-crushing’ force

• Today’s AI tool guide: Turn any UI right into a landing page with Gemini 3 Pro

See you soon,

Rowan, Joey, Zach, Shubham, and Jennifer — the humans behind The Rundown