OpenAI readies GPT-5 for August debut

Good morning, AI enthusiasts. GPT-5 is reportedly coming in August, and OpenAI CEO Sam Altman calls using the model a “here it’s moment.”

As the corporate prepares to drop each its latest flagship system and its first open-weight model in years, the subsequent month could bring a brand new seismic shift in AI’s capabilities — in the event that they can live as much as the large expectations.

Reminder: Our next live workshop is today at 4 PM EST — join and learn the way to construct useful AI agents with ChatGPT and develop into aware of the broader ecosystem of agentic tools. RSVP here.

In today’s AI rundown:

• OpenAI readies GPT-5 for August debut

• AI designs cancer-killing proteins in weeks

• Turn Comet into an AI-powered productivity assistant

• Microsoft maps how employees use AI

• 4 latest AI tools & 4 job opportunities

LATEST DEVELOPMENTS

OPENAI

📆 OpenAI readies GPT-5 for August debut

The Rundown: OpenAI is reportedly planning to launch its next-gen GPT-5 in August, in line with a report from The Verge — with CEO Sam Altman also speaking in regards to the latest model this week in a conversation with comedian Theo Von.

The small print:

• GPT-5 will mix language capabilities with o3-style reasoning into one system, eliminating the necessity to choose from models for various tasks.

• Sam Altman described testing GPT-5 as a “here it’s moment,” claiming it immediately solved questions that made him feel “useless relative to the AI.”

• Altman said GPT-5 can be released “soon” but noted it can not have the capabilities used to realize the recent gold medal on the IMO competition.

• OAI also reportedly plans to release its first open-weight model since 2019 by the top of July, following a delay in its initial launch date because of safety tests.

Why it matters: Each GPT-5 and the open-weight model include months of hype and intensely high expectations, but this next generation of models appears like a real step into the unknown. With Altman and others openly talking about existential shifts and mind-blowing capabilities, August could possibly be the subsequent major raising of the AI bar.

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AI & CANCER RESEARCH

🔬 AI designs cancer-killing proteins in weeks

The Rundown: Scientists from the Technical University of Denmark just developed an AI platform that designs custom proteins in weeks fairly than years, enabling immune (T) cells to focus on and destroy cancer cells.

The small print:

• The system leverages three AI models to design “minibinder” proteins that attach to T cells, giving them “molecular GPS” to locate cancers like melanoma.

• Researchers used the platform to design proteins for each common and patient-specific cancer markers, showing potential for tailored treatments.

• The platform also includes virtual safety screening to predict and eliminate designs that may attack healthy cells before any lab testing begins.

• It uses Google’s Nobel Prize-winning AlphaFold2 to predict proteins, with designs and testing happening in weeks versus years with other methods.

Why it matters: One other day, one other AI medical breakthrough — and the sheer testing time compression these systems enable is resulting in a flood of recent discoveries. It also shows the potential of a “personalized medicine” future, with AI eventually having the ability to quickly design treatments tailored to the needs of every patient.

AI TRAINING

📅 Turn Comet into an AI-powered productivity assistant

The Rundown: On this tutorial, you’ll learn the way to use Perplexity’s Comet AI browser to connect with your calendar and email and get intelligent summaries, event management, and automatic company research based in your meetings.

Step-by-step:

2. Get quick overviews: “What’s on my calendar next week?”

3. Reschedule with communication: “Move my tennis event to Friday, twenty fifth, same time, and draft an email to the participant asking if that works”

4. Research and prep questions: “I actually have two calls on Wed, are you able to give me the most recent AI news about those two firms and prepare me 3 inquiries to ask”

Pro tip: Use the research and query prep feature before every business meeting to steer more productive conversations.

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Within the report, you’ll learn:

• Detailed breakdowns of offerings from OpenAI, Amazon Bedrock, Azure, and Fiddler AI

• Value metrics covering latency, cost, and accuracy for each application size

• Security performance across jailbreak resistance, toxicity control, and faithfulness

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AI RESEARCH

💼 Microsoft maps how employees actually use AI

The Rundown: Microsoft just analyzed 200,000 conversations with Bing Copilot to disclose the roles and tasks individuals are currently delegating to AI, investigating which occupations can be most and least impacted by the rapidly transforming workforce.

The small print:

• Essentially the most common user requests involved gathering info and writing content, with AI most steadily acting as a teacher, advisor, or info provider to users.

• An “AI applicability rating” linked AI usage to occupations, with data showing the very best impact for computer science, office support, sales, and media roles.

• Jobs with low impact scores included those with hands-on tasks like phlebotomists, nursing assistants, maintenance employees, and surgeons.

• Researchers found a weak correlation between wages and AI exposure, which matches against predictions that prime earners could be disrupted by the tech.

Why it matters: This data shows a practical link between what AI excels at and where those skills translate on to within the job market, and lots of the highest exposures are already facing those massive disruptions. Plus — despite the massive advances with robotics, it appears physical and hands-on jobs are still the safest bet (for now).

QUICK HITS

🛠️ Trending AI Tools

• 🤖 Moby Agents – Triple Whale’s AI agent suite for e-commerce

• ⚡️ GitHub Spark – Create full-stack apps with natural language prompts

• 🧠 Ash – AI mental health app for anxiety, stress, and growth

• 💎 Opal – Construct and share AI mini-apps with natural language

💼 AI Job Opportunities

• 💵 Glean – Accounts Payable Analyst

• 🤝 UiPath – Enterprise Account Executive

• 📈 Meta – Growth Marketing Manager, B2B AI

• 🔧 Perplexity AI – Quality Engineer, Comet

📰 The whole lot else in AI today

Elon Musk posted that X is planning to revive Vine, “but in AI form” — with the beloved video app’s IP currently owned by Twitter (now X).

Similarweb published an update to its AI platform data, with OpenAI’s ChatGPT still accounting for 78% of total traffic share and Google in second at 8.7%.

HiDream released HiDream-E1.1, a brand new updated image editing model that climbs to the highest spot in Artificial Evaluation’ Image Editing Arena amongst open-weight models.

Alibaba released Qwen3-MT, an AI translation model with support for 92+ languages and powerful performance across benchmarks.

Figma announced the overall availability of Figma Make, a prompt-to-code tool that enables users to remodel designs into interactive prototypes.

Google introduced Opal, a brand new Labs experiment that converts natural language prompts into editable, shareable AI mini apps with customizable workflows.

COMMUNITY

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See you soon,

Rowan, Joey, Zach, Alvaro, and Jason—The Rundown’s editorial team